Chelsea Handler is vaccinated, horny and ready to get back on stage.

The comedian is launching a standup comedy show, the “Vaccinated and Horny Tour,” this summer through the end of 2021, Variety has learned.

Handler has set 40 nationwide dates with tickets going on sale Friday, June 18. Live Nation is handling the tour.

The tour comes as live events are slowly becoming to come back following a year and a half of concerts, shows, comedy and theater being shut down due to the coronavirus pandemic. With vaccinations rolling out, Handler wants the world to know that she is vaccinated — and horny, hence the title of her latest show.

“Never have I been so confident about my decision-making in remaining childless and alone than I did during this pandemic. I can’t count how many times I high-fived myself every time a friend used the term ‘homeschooling,’ ” Handler tells Variety. “But, as a permanent single professional, I do like to get my groove on, and the best way to get that across is to make it the title of the tour. Now, everyone will know that I’m horny. And that I’m vaccinated.”

Handler — who most recently received rave reviews for her HBO Max standup special “Chelsea Handler: Evolution” — believes that laughter is the best medicine after a global pandemic and to bring people back together.

“I’m so excited to get back on stage because this is the time for people to come together in large groups again, and I want to be a reason people come together. My job is to bring joy and laughter and comfort to as many people as I can. This is the moment to light up and live it up,” she says. “I’ve done a few shows at some smaller clubs to prepare for this tour, and the feeling of laughter in large groups is the thing that everyone will realize they missed the most. We have to heal ourselves, and the fastest way to heal is through laughter.”

“Vaccinated and Horny” marks Handler’s first tour since 2019. Prior to the pandemic, she went on her “Life Will Be the Death of Me Tour,” based on her most recent book.

Over time, and especially in recent years, as she’s gone from E!’s “Chelsea Lately” to a mega Netflix deal and finally to HBO Max in 2020, Handler has evolved from raunchy comedian to activist, and her passion for social justice issues and human rights has been infused into her comedy brand.

“Evolution,” her first standup special in six years, covered her journey through therapy and deftly mixed serious subject matter like race, white privilege and sexual harassment with comedy.

Speaking about her upcoming summer tour, Handler cracks, “This tour is so different than my past standup tours, because I’m an adult who has done this now for 20 years, and I can finally say I’m a professional.”

Handler hosted E!’s “Chelsea Lately” for seven years as the only woman in late-night talk when the show premiered in 2007. In 2016, she launched her documentary series “Chelsea Does” and a talk show on Netflix. She has written six best-selling books, and recently launched an advice podcast with iHeart Radio called “Dear Chelsea.”

See the “Vaccinated and Horny Tour” dates below:

Saturday, July 10, 2021 – Las Vegas – Mirage Theater

Saturday, August 21 – Santa Barbara Bowl – Santa Barbara, CA

Sunday, September 5 – Humphreys Concerts by The Bay – San Diego, CA

Thursday, September 30, 2021 – Cincinnati, OH – Taft Theatre

Friday, October 1, 2021 – Detroit, MI – The Fillmore Detroit

Saturday, October 2, 2021 – Indianapolis, IN – Murat Theatre

Sunday, October 3, 2021 – Grand Rapids, MI – DeVos Performance Hall

Thursday, October 7, 2021 – Norfolk, VA – Chrysler Hall Theatre

Friday, October 8, 2021 – Hanover, MD – The Hall at Live!

Saturday, October 9, 2021 – Cleveland, OH – MGM Northfield

Thursday, October 14, 2021 – Boston, MA – Orpheum Theatre

Friday, October 15, 2021 – Albany, NY – Palace Theatre

Saturday, October 16, 2021 – New York, NY – Beacon Theatre

Thursday, October 21, 2021 – San Jose, CA – San Jose Civic

Friday, October 22, 2021 – Reno, NV – Silver Legacy Grande Exposition Hall

Saturday, October 23, 2021 – Maricopa, AZ – Harrah’s AK-Chin

Wednesday, October 27, 2021 – St. Petersburg, FL – Mahaffey Theater

Thursday, October 28, 2021 – Miami, FL – The Fillmore Miami Beach

Friday, October 29, 2021 – Orlando, FL – Hard Rock Live

Saturday, October 30, 2021 – Jacksonville, FL – Moran Theater

Thursday, November 4, 2021 – Rochester, NY – Kodak Theater

Friday, November 5, 2021 – Buffalo, NY – Kleinhans Music Hall

Saturday, November 6, 2021 – Syracuse, NY – The Oncenter Crouse Hinds Theater

Thursday, November 11, 2021 – Denver, CO – Paramount Theatre

Friday, November 12, 2021 – Chicago, IL – Chicago Theatre

Saturday, November 13, 2021 – Columbus, OH – Palace Theatre

Thursday, November 18, 2021 – Portland, ME – Merrill Auditorium

Friday, November 19, 2021 – Hampton Beach, NH – Hampton Beach Casino

Saturday, November 20, 2021 – The Grand Theater at Foxwoods Resort Casino – Mashantucket, CT

Friday, November 26, 2021 – Atlantic City, NJ – Borgata

Saturday, November 27, 2021 – Bethlehem, PA – Wind Creek Event Center

Thursday, December 2, 2021 – Madison, WI – Orpheum Theater

Friday, December 3, 2021 – Prior Lake, MN – Mystic Lake

Saturday, December 4, 2021 – Milwaukee, WI – Miller High Life Theatre

Thursday, December 9, 2021 – Austin, TX – Austin City Limits

Friday, December 10, 2021 – Houston, TX – Venue TBA *

Saturday, December 11, 2021 – Irving, TX – The Pavilion at Toyota Music Factory

Thursday, December 16, 2021 – Charlotte, NC – Ovens Auditorium

Friday, December 17, 2021 – Atlanta, GA – Coca Cola Roxy

Saturday, December 18, 2021 – Asheville, NC – Thomas Wolfe Auditorium