Mark Ruffalo will star opposite Emma Stone in Yorgos Lanthimos’ upcoming adaptation of “Poor Things,” from Searchlight Pictures, Film 4 and Element Pictures.

Ruffalo, an Emmy winner and three-time Oscar nominee, joins Oscar winner Stone and four-time nominee Willem Dafoe in the film adaptation of Alasdair Grey’s novel.

Lanthimos will direct and produce the film from a script by Tony McNamara, after pairing on “The Favourite,” for which McNamara earned an Oscar nomination for co-writing the screenplay.

“Poor Things” is a Frankenstein-esque tale set in the Victorian-era, described as a story of “love, discovery and scientific daring,” focusing on a young woman named Belle Baxter (Stone) brought back to life by an eccentric but brilliant scientist.

Ed Guiney and Andrew Lowe of Element Pictures, which has produced all of Lanthimos’ English-language films (“The Lobster,” “The Killing of a Sacred Deer” and “The Favorite”), as well as “Room” and Hulu’s “Normal People,” will produce the film. In addition to starring in the film, Stone will produce the project, under her Fruit Tree banner.

Ruffalo most recently starred in the HBO series “I Know This Much Is True,” for which he won an Emmy and Screen Actors Guild Award. The actor is a three-time Academy Award nominee for his roles in “Foxcatcher,” “The Kids are Alright” and “Spotlight.”

The actor recently wrapped filming on Netflix’s “The Adam Project,” opposite Ryan Reynolds, Jennifer Garner and Zoe Saldana. Next, Ruffalo is set to reprise his role as Bruce Banner in the upcoming Marvel series “She-Hulk,” as well as the animated series “What If?”

Ruffalo is represented by Lighthouse Management & Media, UTA, Relevant and Keith Klevan.