“Call Me By Your Name” director Luca Guadagnino has begun principal photography on his first film set in America, “Bones and All,” starring Timothée Chalamet, Taylor Russell and Mark Rylance.

The project, which is filming on location in the Ohio Tri-State area, marks the first collaboration between Guadagnino and Chalamet since the Oscar-nominated “Call Me By Your Name.” Adapted from the eponymous novel by Camille DeAngelis, the film is directed by Guadagnino and written by his longtime collaborator David Kajganich (“Suspiria,” “A Bigger Splash.”)

Chalamet, Russell and Rylance join a cast that includes André Holland, Jessica Harper, Michael Stuhlbarg, David Gordon-Green, Francesca Scorsese and Chloë Sevigny.

“Bones and All” tells the story of first love between Maren, a young woman learning how to survive on the margins of society, and Lee, a disenfranchised drifter, as they meet and join forces for a roadtrip through Ronald Reagan’s America.

Key behind-the-scenes talent includes production designer Elliott Hostetter, who previously collaborated with Guadagnino on HBO series “We Are Who We Are,” director of photography Arseni Khachaturan and frequent Guadagnino collaborator and costume designer Giulia Piersanti. Make up is by Fernanda Perez and hair by Massimo Gattabrusi. Francine Maisler is the casting director.

A Frenesy Film Company and Per Capita Productions movie, “Bones and All” is produced by Dave Kajganich, Theresa Park for Per Capita Productions, Luca Guadagnino and Marco Morabito for Frenesy Film Company, Francesco Melzi d’Eril and Gabriele Moratti for Memo, Lorenzo Mieli for Fremantle-backed The Apartment Pictures, and Peter Spears for Cor Cordium.

The film is executive produced by Giovanni Corrado and Raffaella Viscardi. Financing comes from Italian companies, namely by The Apartment Pictures, Enzio Ricci’s 3 Marys, Memo, Tender Stories, Adler, Elafood, Elafilm, Manila, Serfis and Wise.

Sales will be handled by The Apartment Pictures, Frenesy Film, Memo and 3 Marys.

Chalamet is represented by UTA; Russell is represented by UTA; and Rylance is represented by CAA, and Jodi Peikoff at Peikoff Mahan. Guadagnino is represented by Range Media Partners, WME, and Carlos Goodman at Goodman, Genow, Schenkman, Smelkinson & Christopher.