It’s up to Dwayne Johnson to save the world, with a giant ape named George on the loose, in the first trailer for New Line’s action adventure “Rampage.”

Johnson portrays a primatologist who keeps people at a distance, but shares a bond with George, a silverback gorilla who has been in his care since birth. But a rogue genetic experiment mutates the gentle ape into a raging creature of enormous size — along with other similarly altered animals across North America, destroying everything in their path.

“You don’t know about the 30-foot wolf?” Johnson’s asked at one point.

The key plot point in the trailer comes when a caged George is put on a jet airline, despite Johnson’s advice: “Having George on that plane is a big mistake.”

We then see George busting out of a cage and the plane winding up on fire over Chicago. Later on, Johnson’s character is piloting a helicopter over a river and observes with his trademark wit, “I was just thinking that the only thing missing is a giant crocodile.”

“Rampage” stars Naomie Harris, Malin Akerman, Jake Lacy, Joe Manganiello, and Jeffrey Dean Morgan alongside P.J. Byrne, Marley Shelton, Breanne Hill, Jack Quaid, and Matt Gerald.

“San Andreas” director Brad Peyton helms from a screenplay by Ryan Engle, Carlton Cuse, Ryan J. Condal, and Adam Sztykiel with a story by Ryan Engle, based on the video game “Rampage.” The film is produced by Beau Flynn, John Rickard, Hiram Garcia, and Peyton.

“Rampage” hits theaters on April 20.