Blade Runner 2049” premiered Tuesday night at the Dolby Theatre in Hollywood in a low-key event without a red carpet celebration — but with a poignant acknowledgement of the recent tragedy in Las Vegas.

“So this week once again we’ve been reminded how precious and fragile life is,” said producer Andrew Kosove in introducing the science-fiction sequel.

The audience included stars Ryan Gosling, Harrison Ford, Jared Leto and Robin Wright, director Denis Villeneuve and  Ridley Scott, who directed the original “Blade Runner.” Producers Broderick Johnson and Cynthia Sikes Yorkin took the stage with Kosove.

“We are also reminded how much we still have to come together as a country,” said Kosove. “But tonight we’re here to celebrate the arts. And in times such as these, the arts are even more crucial to our society than ever. The arts makes us think, they make us laugh, they take us places. Most importantly they remind us of our shared humanity. We ask that you keep doing what you’re doing, but do it louder and bolder than ever before because we all need it so much.”

Kosove also noted that Scott’s original film profoundly influenced culture, cinema, design, fashion and music, and then elicited laughs by saying, “He’s a very talented young filmmaker and we see a big career ahead for him.”

Johnson singled out Ford and Gosling, saying, “We’d like to thank Harrison Ford for returning to play his iconic Rick Deckard character and Ryan Gosling for his questions about everything.”

Sikes Yorkin noted she and her late spouse Bud Yorkin began developing the sequel a dozen years ago. “This is really a promise fulfilled for us,” she added.

Blade Runner 2049” is being distributed domestically by Warner Bros. through its output deal with Alcon Entertainment. Sony is the international distributor and production partner with Alcon Entertainment. The film opens Friday.

The after-party was held in the lot behind the El Capitan Theatre with decor featuring themes from the film, set in a dystopian 2049 Los Angeles, including replicant tanks and bars serving Johnnie Walker.