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Is the end in sight for Dr. Callie Torres on “Grey’s Anatomy?”

Sara Ramirez, who has played Callie since season two on “Grey’s Anatomy,” posted a message on Twitter this week, which led to speculation that she could depart the long-running ABC medical drama.

https://twitter.com/SaraRamirez/status/725430490887413761

Thanking viewers for an “unforgettable” ride and tweeting “that’s a wrap” has many of Ramirez’s Twitter followers posting comments of concern, speculating that the actress may have announced her upcoming exit via the tweet. However, Ramirez did include the hashtag “Season 13,” which could signal her return, as “Grey’s Anatomy” has been renewed for a thirteenth season.

Ramirez’s contract on the show is up this June. While insiders close to the show confirm to Variety that the actress’s deal for future seasons has not been closed, a source cautions that Ramirez’s tweet is not necessarily a red flag — she could simply be celebrating wrapping the current twelfth season. In fact, Ramirez has tweeted similar messages when past seasons have come to a close. (And fans reacted the same way, in response to those tweets.)

ABC declined to comment, as the network does not comment on contract negotiations.

Ramirez’s exit would seem shocking, as her character is a beloved staple on the show, but Callie leaving could fit into “Grey’s” storyline — her partner, Penny (Samantha Sloyan) is eyeing a move to New York and Callie has expressed interest in joining her, along with her daughter with Arizona (Jessica Capshaw).

The departure of major characters is not at all foreign to “Grey’s Anatomy,” which has seen the exits of numerous series regulars throughout its decade-plus run. Most recently, star Patrick Dempsey left the show with his character Derek Shepherd killed off in season eleven. Sandra Oh, Katherine Heigl, Eric Dane, Isaiah Washington and T.R. Knight are among major characters who have also been written off the Shondaland hit.

Ramirez first appeared in “Grey’s Anatomy” season two and was upped to a series regular in the third season.