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USA Network has announced the eighth and final season of “Royal Pains” will kick off on Wednesday, May 18, at 10 p.m.

The final installment of the series — which stars Mark Feuerstein, Paulo Costanzo, Reshma Shetty, Brooke D’Orsay, Ben Shenkman and Campbell Scott — will include a musical episode and a sojourn to Hong Kong. The Hamptons-set series will also celebrate its 100th episode midway through the season.

“Under the direction of talented showrunners Michael Rauch and Andrew Lenchewski, our entire ensemble cast led by Mark Feuerstein, and amazing crew, ‘Royal Pains’ took viewers on a remarkable, unforgettable journey for eight wonderful seasons,” said Chris McCumber, NBCUniversal president of entertainment networks. “While summer in the Hamptons may never be the same, this last season promises to be an epic ride.”

Cloris Leachman and Christine Eversole will guest star on the musical episode, while the rest of the season will feature appearances from Annie Potts, Teri Polo, Sebastian Roche, Dan Lauria, Constance Wu, Hal Linden, Ana Ortiz and Maria Dizzia.

Created by Andrew Lenchewski, “Royal Pains” is exec produced by Lenchewski and Michael Rauch. Rich Frank also serves as executive producer along with Jeff Kwatinetz from Prospect Park. Connie Burge, Carol Flint, Jon Sherman and Jessica Ball are also executive producers.