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MTV is diving back into the documentary arena with “Prescription For Change: Ending America’s Opioid Crisis.”

The Oct. 11 premiere of the hourlong doc featuring musican Macklemore and President Obama in a conversation about opioid abuse coincides with the launch of the MTV Docs unit.

“As we continue to push the boundaries of MTV’s storytelling, the importance of providing an open door and blank canvas to creators of all kinds is a top priority,” said Michael Klein, MTV’s exec VP of original content. “Macklemore is the first of many we hope to work with to expose real-life struggles and subcultures that impact the audience.”

MTV has two other docs expected to be released by the end of this year: “Transformation,” a film on transgender youth in Los Angeles, as well as project executive produced by Diplo that chronicles Major Lazer’s concert in Havana earlier this year.

“Prescription for Change” also tells the story of three women seeking to recover from opioid abuse and the struggles addicts face in finding treatment options. “I’m one of millions of Americans who has struggled with addiction and abused pain killers, and if it weren’t for treatment and recovery I wouldn’t be here today,” Macklemore said. “This documentary shines a light on some of the things we need to do to address this epidemic.”

Macklemore exec produced “Prescription for Change” for MTV Docs and Punched in the Head Productions.