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Jennifer Esposito is coming on board “NCIS” as a series regular, Variety has learned.

In addition to Esposito joining the CBS drama in season 14, Duane Henry, who guest-starred in the final two episodes of last season, has been promoted to a series regular.

Both new cast members come as “NCIS” undergoes a major change in its upcoming season with the absence of longtime star Michael Weatherly, who will be starring in another CBS drama this fall — new legal procedural “Bull.”

Esposito will play Special Agent Alex Quinn, an experienced agent who left field work and became an instructor at the Law Enforcement Training Center. Gibbs (Mark Harmon) will lure her back into the field as part of his team where he will take advantage of her sharp wit, quick mind and immense talent as a federal agent.

“We couldn’t be happier to have Jennifer Esposito joining us for season 14,” said “NCIS” executive producer Gary Glasberg. “She embodies everything that we hoped for in the character of Quinn and we can’t wait to have her come be a part of our team.”

Esposito is a familiar face on CBS, having starred on “Blue Bloods” and “Judging Amy.” Her other TV credits include “Mistresses,” “Samantha Who?,” “Rescue Me,” “Spin City” and most recently, Showtime’s “The Affair.” She is repped by CAA, Carissa Stewart and attorney Marcy Morris.

As for Henry, the British actor played MI6 Officer Clayton Reeves in a recurring role in season 13. When he was cast, Variety reported there was a strong possibility he would have a larger role in the 14th season. However, Sarah Clarke, who also joined “NCIS” in a recurring role in the 13th season, will not be returning this fall.