Jeffrey Tambor won lead actor in a comedy for “Transparent,” thanking showrunner Jill Soloway and the creative team at Amazon during his speech.

“You changed my life, you changed my career and you changed everything,” Tambor said to Soloway.

As the reigning champ in the category, Tambor was the frontrunner from the start of Emmy season. The veteran actor has received a tidal wave of kudos for his portrayal of the transgender Maura Pfefferman.

Tambor won his first Emmy last year for “Transparent.” He’d previously racked up six nominations, three for HBO’s “The Larry Sanders Show” and two for Fox’s “Arrested Development.”

He ended his speech on Sunday night by asking creatives to give “transgender talent a chance.” “Give them auditions. Give them their story. Do that.

“I would not be unhappy if I were the last cisgender male to play a female transgender on television, we have work to do,” he added.

Anthony Anderson earned his second consecutive nomination for his work as the patriarch of the Johnson family at the center of “Black-ish.” The show made a mark in its second season with its periodic efforts to tackle social issues including racial profiling and the use of the N-word.

The versatile actor has moved freely between comedy and drama projects during his career, from stints on “The Shield” and “Law & Order” to standup performances.

The fourth career nomination was the charm for Will Forte of Fox’s “Last Man on Earth.” The “Saturday Night Live” vet was on his second consecutive bid for “Last Man,” an offbeat comedy featuring Forte as one of the few survivors after an apocalypse.

Forte was also Emmy nommed for his work as a writer in 1998 on CBS’ “The Late Show With David Letterman” and for guest actor in 2013 on NBC’s “30 Rock.”

Aziz Ansari broke into the Emmy race in a big way this year. The “Parks and Recreation” vet scored the auteur’s hat trick with noms for acting, writing and directing on his autobiographical Netflix comedy “Master of None,” plus he nabbed a fourth nom for comedy series.

William H. Macy was on his third consecutive nom for his work as the depraved patriarch of Showtime’s “Shameless.” The actor previously won an Emmy for the 2003 telepic “Door to Door.” He was also Oscar-nommed for supporting actor for 1996’s “Fargo.”

Thomas Middleditch went all the way on his first try at the Emmys for his role as the neurotic tech genius Richard Hendricks on HBO’s “Silicon Valley.” The Canadian actor has emerged as an much sought-after comedy player after his three seasons on the show.