Kathy Bates’ first Emmy — after 10 previous nominations — came from an unexpected role. The Oscar winner scored the accolade for her guest spot on a 2012 episode of “Two and a Half Men” playing … wait for it … the ghost of Charlie Harper, the character created by Charlie Sheen. The casting was nothing short of genius.

Chuck Lorre, the creator of “Two and a Half Men,” had never met Bates before. “But when I pitched the idea to her, she immediately got the surreal, twisted nature of the whole thing,” he says.

It was the start of a beautiful relationship, one that will continue when Bates headlines the Netflix comedy “Disjointed” from Lorre and David Javerbaum, a former head writer on “The Daily Show.” “I can’t wait to work with Chuck again,” she says. “It’s going to be a really fun, interesting show.”

Lorre says: “Kathy plays Ruth Whitefeather Feldman, a woman whose lifelong mission has been to decriminalize marijuana. She’s something of an icon in that movement. The series is about what happens when that mission is accomplished. She is faced with running a legal cannabis establishment with her son and a staff of young budtenders. Business, family, and romance are difficult — they’re harder stoned.”

Lorre is known for putting together great ensembles, such as “The Big Bang Theory,” and Bates says “Disjointed” is no exception. “Chuck is so great at casting and he’s already putting together some exciting young actors,” Bates notes. That includes Jessica Lu, whom Bates worked with on “American Horror Story: Hotel” last year. “I think she’s one of the kids I killed,” Bates notes. (Spoiler alert: she did.) Also announced are Aaron Moten and Dougie Baldwin.

Lorre says he’s excited to get back to work with Bates. “She epitomizes ‘the show must go on’ ethos,” he notes. “The night we shot the ‘Two and a Half Men’ episode, she broke her toe an hour before show time. I was ready to shut it down, but she insisted on performing. And she did. And she was amazing — hilarious and flawless.”