Craig Ferguson hosted NBC’s second annual Red Nose Day telecast, held at Universal Studios Stage 1 lot on Thursday, and there was no shortage of laughter and applause from the live studio audience as they sat front row to all of the action.

“Well, I got my first call,” a boastful Mila Kunis remarked to husband Ashton Kutcher, sparking laughs from the audience. The actress sat on the first rotation of celebrity panelists. “That’s right! Energy people, energy!” she yelled while leaving the stage.

“The Big Bang Theory” star Johnny Galecki had his share of fun with the audience as well, throwing his red nose into the crowd; Ravi Patel and Yvette Nicole Brown took selfies throughout the show; and Lamorne Morris gave the crowd a slight scare when he jumped up from his seat and yelled to his caller jokingly: “Who is this?!”

Ferguson busted a few dance moves while Paul Shaffer and the Red Nose Orchestra jammed out to “Ain’t Too Proud to Beg” and “Happy.” He also threw in a few light-hearted jokes of his own.

“Are you all the press?” asked Ferguson, pointing to the section of journalists. “I can tell. I feel judged.”

“Do you have a prompter or should I start making up shit,” he joked before going back on air.

The live taping featured a mixture of comedy sketches, musical performances and short docu-videos featuring celebrities such as Julia Roberts, Jack Black, and Ludacris spotlighting challenges children face around the world. Elton John and Blake Shelton also performed during the event.

Pictured: (l-r) Paul Telegdy, President, Alternative and Late Night Programming, NBC Entertainment; Host, Craig Ferguson; Doug Vaughan, Executive Vice President, Special Programs and Late Night Programming, NBC Entertainment -- ()

(Pictured: Paul Telegdy, NBC Entertainment president of alternative and late night programming; Craig Ferguson; Doug Vaughan, NBC Entertainment executive VP of special programs and late night programming)