Mary-Louise Parker will star in a Broadway transfer of the well-received Off Broadway play “Heisenberg,” which will open at Manhattan Theater Club’s Samuel J. Friedman Theater in the fall.

Parker and Denis Arndt, who appeared last year in the world premiere of the two-character Simon Stephens play (pictured above), will reprise their roles in the Broadway production under the direction of returning director Mark Brokaw. Parker plays a woman whose unexpected encounter with older man (Arndt) leads to an ongoing, uncertain relationship. Both performers earned critical raves from the Off Broadway premiere of the show, which was also produced by MTC.

Parker won a Tony in 2001 for her performance in “Proof,” a Broadway transfer of another play that premiered Off Broadway at MTC. She’s since reunited with the theater to star in Broadway stagings of “Reckless” (in 2004) and in “The Snow Geese,” the 2013 play that was Parker’s last Broadway credit.

Stephens penned the stage adaptation of “The Curious Incident of the Dog in the Night-Time,” which has been running on Broadway for more than a year. His plays “Harper Regan” and “Punk Rock” have also gotten New York runs in recent seasons.

“Heisenberg” begins Broadway previews Sept. 20 ahead of an Oct. 13 opening at the Friedman. The show joins a 2016-17 season at MTC that also includes Off Broadway titles “Vietgone” by Qui Nguyen and “Sell/Buy/Date” by Sarah Jones.