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Comedienne Whitney Cummings will make her directorial debut with relationship comedy “The Female Brain,” with shooting starting in Los Angeles in July.

Cummings will direct from her own script, which she co-wrote with Neal Brennan. Cummings will also appear in the film, based on Louann Brizendine’s book of the same name about couples who demonstrate the workings of primal neurology in their romantic relationships.

Black Bicycle Entertainment is financing and Erika Olde will produce alongside Night and Day Pictures’ Michael Roiff. Casting is currently underway.

Cummings was the creator and star of the NBC sitcom “Whitney,” which was cancelled in 2013 after two seasons, as well as the co-creator of the CBS sitcom “2 Broke Girls.” She was most recently seen in HBO’s stand-up comedy special “Whitney Cummings:  I’m Your Girlfriend,” and is currently filming Denise Di Novi’s “Unforgettable” for Warner Bros.

“‘The Female Brain’ is a book that profoundly changed my life, and I’m really proud of how Neal Brennan and I wrote the script in a way that addresses how both men and women are often challenged and undermined by their reptilian brains and primordial fears,” Cummings said. “I’m really grateful Black Bicycle is letting me make a science comedy!”

Black Bicycle is producing and financing Hallie Meyers-Shyer’s “Home Again” with Rose Byrne attached to star. The company is financing and producing Claire and Jake Scott’s “The Burning Woman.”

Cummings is represented by CAA and Mosaic. Olde is also represented by CAA, which represents the film’s worldwide distribution rights.