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Yet another high-profile executive is exiting the Weinstein Co.

Dan Guando, the U.S. head of acquisitions and production, is leaving his job at the company’s Manhattan headquarters, Variety has learned.

Guando is a highly respected 12-year-veteran of TWC, who oversaw the acquisition and release of dozens of movies, like Oscar heavyweights “The Imitation Game,” “The Artist,” “Carol” and “Philomena,” as well as critically beloved indies “Blue Valentine,” “Snowpiercer,” “Fruitvale Station,” “The Grandmaster” and “Begin Again.” He was not only involved with movies that were produced internally from the script stage, but he also drove TWC’s big purchases at film festivals from Sundance to Toronto and Cannes.

He previously worked for Harvey Weinstein at Miramax.

“Dan has been my right hand for the last twelve years,” Weinstein said in a statement. “He started as my assistant, and immediately had the brilliant eye of a producer. He had an innate sense for every facet of the industry. He’s one of the most well rounded executives in the industry and one of the best, most decent human beings I know.”

Guando is the second executive to leave the company this week, though sources say the departures aren’t related. Longtime publicity head Dani Weinstein is stepping down, after 16 years with Harvey. She will be replaced by co-publicity heads Nicole Quenqua and Marguerite Michael, a promotion that was made public on Thursday afternoon.

No decision has been made yet about who will replace Guando.

The Weinstein Co. announced last year that it will be releasing fewer independent films to focus more attention on its TV division. Only three movies will come out in the fall: “Lion,” starring Dev Patel and Nicole Kidman, scheduled to debut at Toronto; “The Founder,” about McDonald’s impresario Ray Kroc (Michael Keaton); and “Gold,” a Christmas-timed adventure film with Matthew McConaughey.