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Oscar Isaac is in talks to co-star with Natalie Portman in Paramount’s adaptation of Jeff VanderMeer’s novel “Annihilation,” sources confirmed to Variety.

Isaac’s “Ex Machina” director Alex Garland is writing and directing, with Gina Rodriguez and Jennifer Jason Leigh also on board to star. The story follows a biologist, to be played by Portman, as she embarks on a four-person expedition into Area X, a territory cut off from civilization. While there, she must deal with a mysterious contamination, disappearing colleagues, a deadly animal and a being known as the Crawler, all while searching for clues regarding her husband’s disappearance.

Isaac will play Portman’s husband, who may not have disappeared after all.

Scott Rudin is producing “Annihilation.”

The pic will reteam Garland with Isaac, who co-starred with Alicia Vikander and Domhnall Gleeson in “Ex Machina.” Isaac followed that up with his Golden Globe-winning performance in the HBO miniseries “Show Me a Hero,” and also appeared in “Star Wars: The Force Awakens.”

He can be seen next in “X-Men: Apocalypse” and also has the Terry George drama “The Promise” bowing later this year. He is currently filming George Clooney’s “Suburbicon.”

Isaac is repped by UTA and Inspire Entertainment.