Joaquin Phoenix is in talks to co-star with John C. Reilly in “The Sisters Brothers.”

Jacques Audiard is directing the indie feature, which is based on the Patrick DeWitt novel.

Reilly optioned the rights to the book and will produce through his shingle with Michael De Luca recently joining the project as a producer. The story follows two brothers — Eli and Charlie Sisters — hired to kill a prospector who has stolen from their boss. The story takes place in Oregon in 1851. The book won the 2012 Stephen Leacock Memorial Medal for humor writing.

The pic is Audiard’s follow-up to his Palme d’Or winning “Dheepan”, which premiered at last year’s Cannes Film Festival. Production is set to start sometime this summer.

Phoenix is currently weighing the offer to play Jesus Christ in “Mary Magdalene” opposite Rooney Mara. Both roles fall into Phoenix’s wheelhouse of strong material helmed by well-respected auteur directors like “The Master” with Paul Thomas Anderson and “Her” with Spike Jonze.

Phoenix was most recently seen in Woody Allen’s “Irrational Man” opposite Emma Stone. He is repped by WME and Sloane Offer.

The news was first reported by Deadline Hollywood.