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Rose Byrne is in negotiations to star in the comedy “Home Again.” The film centers on a recently separated mother of two, who takes in three young men, with charm to spare.

Hallie Meyers-Shyer will write and direct the film, with “It’s Complicated” director Nancy Meyers producing the film. Black Bicycle Entertainment will finance the picture, with the company’s founder Erika Olde also serving as a producer.

Shooting will begin in August in Los Angeles with MadRiver Pictures introducing the film to international buyers in Cannes. CAA is selling the North American rights.

Byrne co-stars in this summer’s “Neighbors 2: Sorority Rising.” She also appeared in “X-Men: First Class,” “Bridesmaids,” and “Insidious,” as well as headlined the FX series “Damages” opposite Glenn Close.

Meyers-Shyer is represented by WME and Byrne, Meyers and Olde are represented by CAA.

Black Bicycle Entertainment’s upcoming credits include Claire and Jake Scott’s “The Burning Woman” and “November Criminals” starring Ansel Elgort and Chloë Grace Moretz for Sony Pictures Worldwide Acquisitions.