Rob Riggle has been cast in the lead role of Fox’s pilot “48 Hours Til Monday,” alongside “Saturday Night Live” alum Jane CurtinVariety has learned.

The single-camera, 30-minute sitcom follows a husband’s “desperate struggle to not let every weekend go completely to hell.”

Riggle will play said husband, Charlie Bishop, described as an energetic, over-committed, yet blindly confident father of three kids who’s happily married to his wife Kelly. At work all week, Charlie relies on weekends to reconnect with his family and be a hands-on father, unlike his own growing up.

Curtin will play Riggle’s mother-in-law, Louise McGill, a wry and fun cigarette-smoking mother, who lives at the home of her grown daughter Kelly (yet to be cast) and her husband Charlie (Riggle), along with her own husband Doug (yet to be cast). Forced to babysit, Louise (Curtin) has a relaxed attitude toward raising children, and has no problem leaving her three grandchildren alone, while she and Doug walk to the MiniMart.

The series from Universal Television comes from Charlie Grandy (“The Daily Show”), who penned the pilot and will also serve as exec producer with Peter Traugott and Rachel Kaplan (“Manhattan Love Story,” “Do No Harm”).

Most recently, Curtin appeared on “SNL’s” 40th anniversary special, making a “Weekend Update” cameo with Tina Fey and Amy Poehler.

Curtin is repped by ICM Partners, and Riggle is repped by WME.