“These three women are changing the world,” “The Ellen Show” tweeted on Monday along with a photo of the trio.
The presidential candidate’s last big national interview came last month with CNN’s Brianna Keilar.
Clinton also appeared on the daytime talk show in 2007, the first time she was vying for the Oval Office. Clinton famously discussed supporting civil unions, but not gay marriage.
The new season of “The Ellen Show” premieres September 8 on NBC.