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Rob Lowe (“Parks and Recreation”), Megan Mullally (“Will & Grace”) and Jenna Fischer (“The Office”) are set to star in NBC’s “Apocalypse,” the net announced Wednesday.

The hourlong dramedy about the last days of mankind is a co-production with Sky TV.

The series, slated for 10 episodes, follows an extended family whose lives unexpectedly cross paths, just as the news of an impending comet colliding with Earth hits. The characters — some of whom are destined to live in a bunker below ground — are described as a foul-mouthed priest, an unhinged white supremacist, a mild-mannered bank manager, a germophobic cyberterrorist, a five-star general and a child who possibly rose from the dead.

The series also stars British actors Matthew Baynton, Paterson Joseph and Joel Fry.

“This is an out-of-the-box and wholly original project that offers just the right combination of both high drama and humor,” said Jennifer Salke, president of NBC Entertainment. “With a stellar cast that includes Rob Lowe, Megan Mullally, Jenna Fischer and Matthew Baynton — all four who know how to expertly balance those lines — we’re ready to dive into the ‘Apocalypse.'”

Creator Iain Hollands (“Beaver Falls”) will write the series and Michael Engler (“30 Rock”) will direct the first two episodes. Juliette Howell, Tim Bevan, Eric Fellner and Lynn Horsford will exec produce for Working Title TV, alongside Andrew Conrad for Bigballs Films, plus Cameron Roach and Lizzie Gray for Sky. The series, commissioned by Sky 1, will be produced by Polly Buckle, Nick Pitt and Susie Liggat.

Filming will begin later this month.