Rachel Dratch and Holland Taylor have signed on to star Off Broadway in “Ripcord,” the new stage comedy by David Linsday-Abaire, the playwright who won the Pulitzer for “Rabbit Hole.”

Taylor, the “Two and a Half Men” Emmy winner who appeared on Broadway in the 2013 solo play “Ann,” will replace the previously announced Mary Louise Wilson, who had pull out because of an extension of the book tour for her recent memoir, “My First Hundred Years in Show Business.” Taylor will appear alongside Marylouise Burke as dueling roommates at an assisted living facility.

Dratch, who recently appeared in Off Broadway’s “Tail! Spin!” and a musical adaptation of “Love’s Labour’s Lost” in Central Park, also joins the cast of the show, to be directed by David Hyde Pierce (whose Broadway staging of musical “It Shoulda Been You” closes Aug. 9).

Lindsay-Abaire wrote the screenplay for the recent “Poltergeist” remake, and also has writing credits on movies including “Robots,” “Rise of the Guardians” and “Oz the Great and Powerful.” Manhattan Theater Club, the New York nonprofit producing “Ripcord,” has previously bowed Lindsay-Abaire plays including “Good People,” “Rabbit Hole” and “Fuddy Meers.”

Pierce leads a creative team that also includes Alexander Dodge (sets), Peter Kaczorowski (lights), Jennifer von Mayrhauser (costumes) and John Gromada (sound and music).

“Ripcord,” set for a run this fall at MTC’s Off Broadway venue, is part of an MTC season that also includes “Fool for Love,” starring Sam Rockwell and Nina Arianda on Broadway, as well as Linda Lavin in Richard Greenberg’s “Our Mother’s Brief Affair” and, Off Broadway, the world premiere of the latest play by John Patrick Shanley, “Prodigal Son.”

An MTC commission, “Ripcord” begins previews Sept. 29 ahead of an Oct. 20 opening at New York City Center’s Stage I. Further casting remains to be set.