Joshua Jackson, the “Fringe” and “Dawson’s Creek” alum who’s currently starring in Showtime’s “The Affair,” will make his Off Broadway debut in the Second Stage Theater production Lydia R. Diamond’s “Smart People,” appearing alongside a cast that also includes Mahershala Ali (“House of Cards”).

Kenny Leon, who picked up a Tony Award for his 2014 staging of “A Raisin in the Sun” and directed the 2011 Broadway run of Diamond’s “Stick Fly,” directs a cast that also includes Anne Son and Tessa Thompson. The storyline of “Smart People” centers on the tangle of personal relationships between four Harvard intellectuals on the eve of Barack Obama’s first election.

Jackson has appeared on the West End in David Mamet’s “A Life in the Theater.” Ali, meanwhile, was recently cast in upcoming Netflix series “Luke Cage,” which airs next year, while Thompson has appeared in movies including “Dear White People” and “Selma,” and has a role on next year’s HBO series “Westworld.”

“Smart People” will open at Second Stage Theater’s Off Broadway space in a run that’s slotted in between upcoming fall musical “Invisible Thread” and spring musical outing “Dear Evan Hansen.” One more show remains to be announced to round out the company’s 2015-16 season.

“Smart People” begins previews Jan. 26 ahead of a Feb. 11 opening.