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Jessica Lange will star on Broadway, for the first time in more than a decade, in “Long Day’s Journey Into Night,” appearing alongside Gabriel Byrne and John Gallagher Jr. in a spring 2016 revival of the Eugene O’Neill drama.

Roundabout Theater Company, the New York nonprofit that last season produced shows that starred Ewan McGregor (“The Real Thing”) and Emma Stone (“Cabaret”), presents the production in association with Ryan Murphy, the TV force (“Glee,” the upcoming “Scream Queens”) who’s worked with Lange on four seasons of “American Horror Story.” British director Jonathan Kent (“Faith Healer,” “Hamlet” with Ralph Fiennes) helms.

Lange will play Mary Tyrone, a woman in the grip of morphine addiction, in O’Neill semi-autobiographical play, returning to the part after playing it on the West End in 2000. It’s one of the great female roles of American drama, as were the parts Lange tackled in her two prior Broadway appearances, “The Glass Menagerie” (2005) and “A Streetcar Named Desire” (1992).

Byrne, who stars as Tyrone family patriarch James, last appeared on Broadway in another Roundabout revival of an O’Neill play, “A Touch of the Poet,” in 2005. Gallagher (“The Newsroom”), a Tony winner for “Spring Awakening,” will play son Edmond in “Long Day’s Journey” after previously appearing on Broadway in shows including “Jerusalem” and “American Idiot.”

Roundabout’s latest O’Neill revival joins a starry, 50th anniversary season from the company that includes Clive Owen in “Old Times” and Keira Knightley in “Therese Raquin.” “Long Day’s Journey” begins previews March 31, 2016, ahead of an April 19, 2016, opening at the Roundabout’s American Airlines Theater.