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Carrie Coon, whose recent screen work includes “Gone Girl” and HBO series “The Leftovers,” has jumped into an Off Broadway production this spring, taking on the lead role of “Placebo,” the new play by Melissa James Gibson.

Coon, nominated for a 2013 Tony for her performance in the revival of “Who’s Afraid of Virginia Woolf?,” takes over for Kristen Connolly (“House of Cards”), who exits the show for a TV commitment. Coon will join a cast that already includes William Jackson Harper, Alex Hurt and Florencia Lozano.

The latest play by Melissa James Gibson, whose TV resume includes “The Americans ” and “House of Cards,” centers on a woman (Coon) at work on study of a new female arousal drug, and the ways in which the questions raised in her professional work begin to echo issues at home. Daniel Aukin (“4,000 Miles”) directs.

“Placebo” begins previews Feb. 20 ahead of a March 16 opening at Off Broadway’s Playwrights Horizons.