LONDON — “Friends” star Matthew Perry will lead the cast in the world premiere of his playwriting debut, “The End of Longing,” at the Playhouse Theatre, London, from Feb. 2 to May 14.

The fast-paced, bittersweet comedy will be directed by Lindsay Posner (“Speed-the-Plow,” “Other Desert Cities”) reuniting the pair, following their first West End collaboration on “Sexual Perversity in Chicago” at the Comedy Theatre in 2003.

“The End of Longing” centers on Jack, Stephanie, Joseph and Stevie, four lost souls, entering their forties and searching for meaning. After sharing one raucous night together in a downtown Los Angeles bar, their lives become irreversibly entwined in a rollercoaster journey that forces them to confront the darker sides of their relationships.

Further casting for this four hander will be announced shortly.

Perry said: “Being on stage makes you feel naked. Being on stage in a play that I have written will make me feel doubly naked. So if you’d like to see me doubly naked, tickets go on sale today.”

Perry is best known for playing Chandler Bing in comedy series “Friends,” which ran from 1994 to 2004. He is the star and executive producer on CBS’s “The Odd Couple,” the comedy by Neil Simon. The series debuted as the biggest new comedy of the 2014 season, with over 13 million viewers. The second season will premiere in 2016. Previous to this Perry starred in and co-executive produced NBC’s comedy “Go On,” and has twice guest starred on “The Good Wife.” In 2011 Matthew was the executive producer, co-writer and star of the ABC show “Mr Sunshine.” He received Emmy, Golden Globe and SAG Award nominations for his starring role in TNT’s “The Ron Clark Story,” and in 2006 starred in Aaron Sorkin’s NBC drama “Studio 60 on the Sunset Strip,” in a role that was written for him. He also received an Emmy nomination for outstanding guest actor in a drama series for his role as Joe Quincy in “The West Wing.”

Posner’s most recent theater credits include “Dinner with Saddam” and “Communicating Doors” at the Menier Chocolate Factory, “She Stoops to Conquer” at the Theatre Royal Bath, “Hayfever” at the Theatre Royal Bath/Duke of York’s Theatre, and “Speed the Plow” at the Playhouse Theatre.

His production of “A View From the Bridge” at the Duke of York’s Theatre was nominated for four Olivier Awards, and his “Death and the Maiden” at the Royal Court Theatre won two Olivier Awards.

“The End of Longing” is produced by Howard Panter and Adam Speers for the Ambassador Theatre Group.