Lionsgate has released a violence-laden trailer for drug trafficking drama “Sicario,” starring Emily Blunt, Benicio Del Toro, Josh Brolin and Jon Bernthal.

The trailer opens amid ominous music with the warning, “In Mexico, ‘sicario’ means hitman.”

The story, set in the lawless border area between the U.S. and Mexico, centers on an idealistic FBI agent (portrayed by Blunt) who’s exposed to the brutal world of international drug trafficking by members of a government task force — played by Brolin and Del Toro — who have enlisted her in their plan to take out a major Mexican cartel boss.

“Prisoners” helmer Denis Villeneuve directed from a script by Taylor Sheridan. The film premiered last month in competition at the Cannes Film Festival.

Producers are Basil Iwanyk, Molly Smith, Trent Luckinbill, Thad Luckinbill and Edward McDonnell. Production companies are Black Label Media and Iwanyk’s Thunder Road Pictures.

“Sicario” opens Sept. 18 limited release followed by a wide release on Sept. 25.