Paul Rudd and Alexander Skarsgard have come on board the science-fiction thriller “Mute,” with Duncan Jones directing and production starting in March.

Skarsgard will portray a mute bartender in Berlin, 40 years in the future in what has become a roiling city of immigrants, where East crashes against West. His character will be looking for a woman who has disappeared — and when his search takes him deep into the city’s underbelly, an odd pair of American surgeons (led by Rudd’s character) seem to be the only recurring clue.

“Mute” is based on a script by Jones and Mike Johnson and will be produced by Stuart Fenegan under Jones and Fenegan’s Liberty Films banner.

Lotus Entertainment will handle international sales starting at the upcoming American Film Market, which opens Wednesday. CAA arranged for the financing and is handling the domestic sale. Lotus’ Bill Johnson, Jim Seibel and Ara Keshishian will serve as executive producers.

“I’ve been working towards making ‘Mute’ for 12 years now,” Jones said. “I cannot tell you how thrilled I am that we’re finally going to shoot this utterly unique film. The fact that I get to make it with Alexander Skarsgard and Paul Rudd makes it all the more exciting!”

Jones’ credits include “Warcraft,” “Source Code” and “Moon.”

Keshishian negotiated the deal on behalf of Lotus.

Skarsgard recently wrapped production on “Tarzan” for Warner Bros. Rudd completed “Captain America: Civil War” for Marvel.

Skarsgard and Jones are repped by CAA. Rudd is represented by UTA and Brillstein Entertainment Partners.