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Omar Sy, “Life of Pi” thesp Irrfan Khan and Sidse Babett Knudsen are set to join Tom Hanks and Felicity Jones in “Inferno,” the next installment in Dan Brown’s Robert Langdon series for Sony.

Ron Howard is returning as director, producing with Brian Grazer through their Imagine Entertainment banner.

In this latest installment, Langdon finds himself in a hospital room in Venice as well as the target of a manhunt. With the help of Sienna, a nurse, and his knowledge of symbology, he will try to escape while they have to solve the most intricate riddle Langdon has ever faced.

David Koepp adapted the script. The pic is set to bow on Oct. 14, 2016.

“We’re thrilled to be making a third Robert Langdon film with Ron, Tom and Brian,” said Doug Belgrad, president of Sony Pictures Entertainment Motion Picture Group. “’Inferno’ will deliver all of the excitement, intrigue and international adventure that audiences expect from a film based on Dan Brown’s huge-selling Langdon book series. We can’t wait to see this character back on the bigscreen.”

Michael De Luca and Andrea Giannetti will oversee the project for Columbia Pictures.

This franchise has already delivered for Sony, and the studio is hoping for the same with “Inferno.” “The Da Vinci Code” grossed $758 million worldwide while prequel “Angels and Demons” grossed $486 million worldwide.

Khan can be seen next in “Jurassic World” and is repped by Gersh and Brillstein. The CAA-repped Sy’s past credits include “X-Men: Days of Future Past” and “The Intouchables,” and he can be seen next in the untitled John Wells drama.

Knudsen is repped by Troika and can be seen next in “Hologram for a King,” which also stars Hanks.