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Gina Carano will star opposite Ryan Reynolds in Fox-Marvel’s action-adventure “Deadpool,” with Tim Miller directing.

Lauren Shuler Donner is producing “Deadpool,” set for a March start in Vancouver.

Reynolds portrays the title character, a talkative assassin who winds up with superpowers while seeking a cure for his cancer. Carano will play the role of Angel Dust, part of the Morlocks group of mutants in the Marvel universe.

Miller is directing the superhero film from a script by Rhett Reese and Paul Wernick.

Carano, a former MMA star, broke into movies with 2011’s “Haywire” and 2013’s “Fast and Furious 6.” She recently wrapped production on “Bus 657” and the “Kickboxer” reboot.

Reynolds previewed a first look at his character’s signature mask on Twitter earlier this week.

Carano is repped by Gersh, Scott Karp at the Syndicate and Ziffren Brittenham.

News of her casting was first reported by the Hollywood Reporter.