Lauren Shuler Donner is producing “Deadpool,” set for a March start in Vancouver.
Reynolds portrays the title character, a talkative assassin who winds up with superpowers while seeking a cure for his cancer. Carano will play the role of Angel Dust, part of the Morlocks group of mutants in the Marvel universe.
Miller is directing the superhero film from a script by Rhett Reese and Paul Wernick.
Carano, a former MMA star, broke into movies with 2011’s “Haywire” and 2013’s “Fast and Furious 6.” She recently wrapped production on “Bus 657” and the “Kickboxer” reboot.
Reynolds previewed a first look at his character’s signature mask on Twitter earlier this week.
— Ryan Reynolds (@VancityReynolds) February 12, 2015
Carano is repped by Gersh, Scott Karp at the Syndicate and Ziffren Brittenham.
News of her casting was first reported by the Hollywood Reporter.