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Will Smith goes head to head with the NFL in the first trailer for his upcoming sports drama “Concussion.”

“You’re going to war with a corporation that owns a day of the week.”

Based on a 2009 GQ article, the film from Sony Pictures tells the real-life story of forensic neuropathologist Dr. Bennet Omalu, who discovered a link between football injuries and early-onset dementia that could lead to death. He became at odds with the NFL after diagnosing football players, including Dave Duerson (Adewale Akinnuoye-Agbaje) and Andre Waters (Richard T. Jones), with CTE — a brain condition caused by repeated head trauma.

The Nigerian-born doctor made his discovery after performing an autopsy on Mike Webster of the Pittsburgh Steelers.

The movie, written and directed by Peter Landesman, also stars Luke Wilson, Alec Baldwin, Albert Brooks and Gugu Mbatha-Raw.

“Concussion” hits theaters on Christmas Day.