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Alexandra Daddario has joined Kate Upton to star in director William H. Macy’s road-trip sex comedy “The Layover.”

Producers are Keith Kjarval of Unified Pictures and Aaron L. Gilbert of Bron Studios. Executive producers are Patricia Cox and Jason Cloth of Creative Wealth Media Finance.

Also starring are Rob Corddry, Kal Penn, Matt Jones and Matt Barr.

Macy will direct from a script by David Hornsby and Lance Krall, who have collaborated on “It’s Always Sunny in Philadelphia,” for which Hornsby was the writer, executive producer and co-star. Daddario and Upton will play a pair of lifelong best friends who decide to avoid their problems by taking a vacation, only to find that their plane has been rerouted due to a hurricane warning.

Daddario stars opposite Dwayne Johnson in “San Andreas,” opening May 29. She’s appeared in HBO’s “True Detective” and the “Percy Jackson” series.

Macy made his directorial debut with the independent drama “Rudderless.” He’ll also have a part in “The Layover.”

WME Global will represent worldwide distribution rights. Daddario is repped by UTA and McKeon Myones Entertainment.