TLC is taking a shot at a latenight talkshow franchise, tapping Margaret Cho to co-host a panel yakker focused on sex.

Cho will host “All About Sex” with fellow comedian Heather McDonald, actress Marissa Jaret Winokur and Dr. Tiffanie Davis Henry, an Atlanta-based sex and relationship counselor. Show is billed as a weekly dissection of all aspects of sex in American culture with a focus on dispelling misconceptions and helping women tackle intimacy problems.

“All About Sex” is set to bow Jan. 10 in the 11 p.m. slot following the highly rated “Sex Sent Me to the ER.” TLC has ordered six half-hour episodes from Relativity Television and Ellen Rakieten Entertainment.

The show’s format is a departure for TLC, which typically favors docu-soap series.