Keanu Reeves will star in science-fiction thriller “Replicas” for Lotus Entertainment and di Bonaventura Pictures.

The announcement comes on the heels of a solid reception of Reeves’ “John Wick,” which opened in second place at the U.S. box office.

“Hysteria” director Tanya Wexler will helm “Replicas” from a screenplay by Chad St. John, based on a treatment developed by Stepehen Hamel and Reeves. Producers are Lorenzo di Bonaventura, Stephen Hamel, Reeves, and Fundamental Films.

Lotus will introduce the film to foreign buyers starting at the upcoming American Film Market. CAA is handling domestic rights. Shooting will start in the spring.

Reeves will portray a neuroscientist whose family is killed in a traffic accident and will stop at nothing to bring them back — pitting himself against a government-controlled laboratory, a police task force and the physical laws of science.

Di Bonaventura noted that he’s eager to work with Reeves again.

“From my experience working with Keanu on ‘The Matrix’ franchise through our collaboration on ‘Constantine,’ I have always been impressed by Keanu’s ability to bring a genuine level of humanity to the sci-fi genre through his performance.  I am looking forward to collaborating with Keanu once again on this unique take on what lengths a person will go to alter the past, and the implications of those actions.”

Reeves is represented by CAA.