Jane Fonda, Reese Witherspoon, Jennifer Lopez, Viola Davis and Universal Pictures Chairman Donna Langley will be honored at Variety‘s sixth annual Power of Women luncheon as Lifetime Impact Honorees for their humanitarian efforts.

“The women of the entertainment industry are among the most passionate champions of philanthropy and affecting change for various causes,” said Michelle Sobrino-Stearns, publisher, Variety. “We’re thrilled to once again honor, through our seventh Power of Women initiative, an outstanding lineup of women who do just that.”

“For over 30 years, Lifetime has been the entertainment industry leader in celebrating women. We are incredibly proud of our longstanding partnership with Variety‘s Power of Women event to showcase the great philanthropic work of some of the leading charitable voices in our industry,” said Nancy Dubuc, President and CEO, A+E Networks.

The Oct. 10 event at the Beverly Wilshire Four Seasons is held in conjunction with the annual Women’s Impact Report in Variety magazine and in partnership with Lifetime Television.

Fonda is being recognized for her work with the Georgia Campaign for Adolescent Power and Potential, which focuses on teen pregnancy prevention and healthy choices. Witherspoon will be honored for her participation in the Malala Fund, which empowers girls through education in developing countriesLopez oversees the Lopez Family Foundation, which works on access to medical care for women and children. Davis supports childhood hunger organization Hunger Is, while Universal’s Langley will be honored for her work with women’s development organization Vital Voices.

The Power of Women event (official hashtag #PowerOfWomen) is now in its sixth year in Los Angeles and launched its debut New York event earlier this year. The exclusive luncheon will host 500 Hollywood insiders who will pay tribute to the philanthropic efforts of the honored women. The afternoon will also include VIP pre- and post-ceremony cocktail receptions with an interactive philanthropy bazaar.

Sponsors include Saint Vintage, Audi, Moroccanoil, Demarest Films and Coca-Cola.