Tech expert and philanthropist Larry Ellison, co-founder and CEO of enterprise software company Oracle Corp. will be honored at the second annual Rebels With a Cause gala March 20 at Paramount Pictures Studios in Hollywood.

The event will feature special guest performances by Barry Manilow and Pharrell Williams and benefits the research of David B. Agus, director of the USC Westside Cancer Center and the USC Center for Applied Molecular Medicine. Late-night host Jimmy Kimmel will serve as the gala’s MC along with honorary co-chairs Cassandra and Brad Grey, chairman and chief executive officer of Paramount Pictures, and Carmen A. Puliafito, dean of the Keck School of Medicine. Grammy winner David Foster will be the evening’s musical director, with Don Mischer taking on production duties.

“Larry has been a champion of our Center’s work from day one when his Ellison Medical Foundation announced funding for the initiation of our cancer research at the USC Center for Applied Molecular Medicine,” Agus said in a statement. “His generous support through the years is allowing us to explore unique approaches to medical oncology that will help us better control a disease which impacts millions worldwide.”

“Cassandra and I are honored to be co-hosting this event. Dr. Agus and his team’s tireless and most innovative efforts towards fighting cancer is what propelled us to support this incredibly worthy cause. Like Dr. Agus and Larry Ellison, the night’s distinguished honoree, we are committed to the profound advancements taking place in the fields of genomics, proteomics and gene sequencing,” Grey said. “For all those who are afflicted with these life-altering diseases, we collectively look forward to the great lifesaving innovations that Dr. Agus and his team have on the horizon tomorrow and for years to come.”

Puliafito added, “At a time when medical research is severely impacted by decreased grant funding from the National Institutes of Health, private donations and foundation gifts are becoming increasingly important to the ongoing pursuit of medical cures and treatments through scientific research. By honoring Larry Ellison, we honor passionate pursuits – in medicine, in business, in philanthropy.”