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Zachary Knighton (“Happy Endings”) and Steven Strait (“Magic City”) are heading for the apocalypse in “Hot,” starring in the indie feature from Caliber Media and Glydascope Inc.

Shoot is starting this week in Los Angeles.

Victor Warren will make his directorial debut from his own adaptation of Daniel Keleher’s play. Noah Segan (“Looper”), Kate Siegel (“Oculus”) and Jessica Dykstra also star.

Dallas Sonnier and Jack Heller are producing alongside Warren, John Schoweiler and David A. Gluck. Ted Weyn and Michael Reidenbach are exec producing.

“Hot” is a look at an apocalyptic future Los Angeles torn apart by a dangerous virus, most of its victims left unconscious to die slowly. Strait and Knighton portray life-long best friends holed up in an ostentatious penthouse with Strait’s character spending his days caring for his comatose fiancee (Siegel).

Keleher is a recipient of the George Burns and Gracie Allen Fellowship for Outstanding Comedy Writing and the Skirball/Kennis Playwrights Award.

Warren brought the project to Caliber, which co-financed with Weyn and Reidenbach

Knighton is repped by UTA, 3 Arts and attorney James Adams. Strait is repped by CAA and 3 Arts. Segan is repped by Untitled. Siegel is repped by TCA/Jed Root. Keleher is repped by ICM and HertzbergMedia.