Story, set at a time when humans are at the bottom of the evolutionary ladder, follows a woman targeted for assassination by the queen of the universe.
It is unknown whom Middleton will play.
Warner Bros. will distribute, and a spring production start date has been set.
Like Booth and Redmayne, Middleton marks another up-and-comer added to the cast and one with a very busy 2013 schedule.
She is set to star in the BBC One’s adaptation of Hitchcock’s “The Lady Vanishes” and can be seen next in Iain Softley’s “Trap for Cinderella.” She can also be seen in Danny Boyle’s “Trance” and “A Long Way Down” with Rosamund Pike and Aaron Paul.
Middleton is repped by UTA and Conway van Gelder Grant in the U.K.