Reese Witherspoon is in talks to topline indie drama “The Good Lie” with Philippe Falardeau (“Monsieur Lazhar”) directing from Margaret Nagle’s screenplay.

Molly Smith’s newly minted production-financing company Black Label Media is producing. Producers are Smith and Black Label Media partners Trent Luckinbill and Thad Luckinbill, along with Imagine’s Brian Grazer, Ron Howard and Karen Kehela Sherwood. Imagine’s Kim Roth and Reliance’s Deepak Nayar are exec producing.

“The Good Lie” follows a young refugee of the Sudanese Civil War who wins a lottery for relocation to the United States with three other lost boys. They develop an unlikely friendship with a brash American woman assigned to help them, but the young man struggles to adjust to his new life and his feelings of guilt about the brother he left behind.

A similar project, “The Lost Boys of Sudan,” was in development at Paramount a decade ago with the late Bobby Newmyer and Damon Lee producing, Brad Silberling directing and Nagle scripting. That project took form after the airing of a “60 Minutes II” segment about the Lost Boys, survivors who fled hundreds of villages burned in Sudan during the late 1980s and who journeyed for years to refugee camps in Kenya.

Nagle developed the “Good Lie” screenplay in the Imagine Writer’s Lab. She won WGA awards for “Warm Springs” and “Boardwalk Empire” and she is adapting the book “Tuxedo Park” for Playtone.

Falardeau was listed on Variety’s “Ten Directors to Watch” list in 2012 and his “Monsiuer Lazhar” was nominated for best foreign language film Oscar last year.

Witherspoon is repped by Management 360 and CAA. Nagle is repped by UTA, Brillstein Entertainment Partners and attorney David Matlof.

Falardeau is repped by UTA.