The Proposal” helmer Anne Fletcher is set to direct the action comedy “Murder Mystery” for the Weinstein Co. and Dimension Films.

The pic will be a co-production between Weinstein, Dimension and Endgame and has James Vanderbilt on board to pen the scirpt.

The pic follows a married couple taking the honeymoon they never had in hopes of saving their struggling marriage, but soon find themselves in the middle of their very own murder mystery when one of their fellow cruise passengers is found dead. They must travel across Europe to discover the true murderer while trying to reignite the spark to their relationship.

Beau Flynn and Tripp Vinson are producing along with Vanderbilt, Endgame Entertainment’s James D. Stern and Charlize Theron through her Denver and Delilah Productions banner.

Fletcher, who is repped by UTA and Clear Talent Group, most recently helmed “The Guilt Trip” starring Seth Rogen and Barbra Streisand. The WME-repped Vanderbilt recently wrote the script to “The Amazing Spider-Man 2” which just wrapped production.