Fundraising telecast “Stand Up to Cancer” is returning for its third primetime broadcast on Sept. 7 at 8 p.m. ET.

Live, one-hour event will air commercial-free simultaneously on the Big Four. Cablers including HBO, Logo and VH1 have also committed to carrying the spesh.

“SU2C” will build upon its two previous broadcasts in 2008 and 2010, which resulted in over $180 million of pledges to cancer research. This year’s telecast is particularly poignant given the recent death of producer and Stand Up To Cancer co-founder Laura Ziskin.

“The theme of the show is hope,” Joel Gallen told Variety. “We want to carry on Laura’s legacy with this year’s ‘Stand Up to Cancer,'”

Gallen, along with Gwyneth Paltrow, will exec produce the event.

Broadcast will feature musical performances, celeb appearances and personal stories of patients triumphing through advanced stage cancer.

“The fact that we’ve been able to galvanize the best scientific minds in the nation around cancer since Stand Up to Cancer’s launch in 2008 is significant,” Entertainment Industry Foundation topper Lisa Paulsen told Variety.

Stand Up to Cancer is an initiative of the EIF, a collective philanthropy for the film and TV businesses.

“In our third broadcast, we’ll be telling America about the progress over the last few years,” Paulsen added.

Telecast has previously landed A-list talent including Jennifer Aniston, Beyonce, Halle Berry, George Clooney and Denzel Washington. This year’s celeb lineup has yet to be announced.

SU2C’s exec leadership council includes Katie Couric, Sherry Lansing, Lisa Paulsen, Kathleen Lobb, Rusty Robertson, Sue Schwartz, Pamela Oas Williams and Ellen Ziffren. Sung Poblete tops the org.