Whitney Cummings is taking over more TV turf with a greenlight from E! for a weekly half-hour yakker to bow later this year.

“Love You, Mean It With Whitney Cummings” will feature the hyphenate riffing on pop culture, celeb gossip, relationships and other topical matters. She’ll have a regular sidekick, Julian McCullough, as well as visits from celeb guests and comedian friends.

“Love You” will bow in the Wednesday 10:30 p.m. slot toward the end of this year, paired with “The Soup.” E! will tout the project at its upfront presentation tonight to advertisers in Gotham.

Cummings is coming off a banner season in which she created, exec produced and toplined her eponymous NBC sitcom and served as co-creator of the CBS hit “2 Broke Girls.”

The E! show marks a homecoming for Cummings, who started to make a name for herself a few years ago as a regular member of the roundtable of comics on Chelsea Handler’s latenight E! skein “Chelsea Lately.” “Love You” is produced by Handler’s Borderline Amazing Prods., with Handler, Cummings and Tom Brunelle serving as exec producers.

“This show gives me a chance to get back to my standup roots,” Cummings said. “And I’m really excited to be able to say (almost) whatever I’d like on TV again.”

“Love You” is part of E!’s push to enhance its comedy lineup. The series has been in development for some time, while the NBCUniversal cabler waited for the right time to launch it given Cummings’ busy sked.

“We’re continuously looking for strong points of view for the comedy programming that is such a key part of our makeup,” said Lisa Berger, E!’s prexy of entertainment programming. “Whitney is someone we identified early on that we wanted to develop with.”

Some of the specifics of the show, which will lense on the same stage at Universal as “Chelsea Lately,” are still being worked out — for example, how many of the traditional talkshow trappings it will have (a couch, a desk, etc.).

“We always try to break the form a little bit and make sure our shows have a unique spin,” Berger said. “But in its inherent form it will have some of the talkshow familiarities.”

Cummings is repped by CAA.