Marlo Thomas will topline a new play by Joe DiPietro, “Clever Little Lies,” in a world preem production at New Jersey regional George Street Playhouse this fall.

DiPietro, who scored the Tony for recently-closed musical “Memphis,” also penned the books for “Nice Work If You Can Get It,” now playing on the Rialto, and for Off Broadway longrunner “I Love You, You’re Perfect, Now Change.” His play “Creating Claire” and the tuner incarnation of “The Toxic Avenger,” for which he wrote the book, also bowed at George Street.

Thomas appeared last season in Broadway’s “Relatively Speaking,” and also has played prior stints at George Street in Elaine May’s “Roger is Dead” (the one-act play in which she appeared in “Relatively”) and Arthur Laurents’ “New Year’s Eve.”

David Saint, the a.d. of George Street, will helm “Clever Little Lies.”

Storyline centers on a mother whose investigation into a secret kept by her son prompts a surprising revelation.

“Lies” runs Nov. 27-Dec. 23, with a press opening set for Nov. 30. Show replaces a previously announced staging of Ken Ludwig’s “The Game’s Afoot.”