The Signature Theater Company has pulled together casts for the initial productions to run at the company’s, soon-to-open multi-stage complex, the Signature Center.

A team of Gotham legit vets has signed on to join Jane Alexander in the company’s revival of Edward Albee play “The Lady from Dubuque.” Thomas Jay Ryan (“In the Next Room, or the Vibrator Play”), Laila Robins (“Frozen”), Michael Hayden, Peter Francis James, Catherine Curtin, C.J. Wilson and Tricia Paoluccio will all appear in the show, to be helmed by David Esbjornson (“The Goat, or Who Is Sylvia?”).

Storyline centers on a small party of six couples at which a mysterious, unexpected guest (Alexander) and her companion (James) arrive. The show, the first in the Signature Center’s End Stage Theater, begins previews Feb. 14 and opens March 5.

In the venue’s Alice Griffin Jewel Box Theater, Colman Domingo (“The Scottsboro Boys”) and Scott Shepherd (“Gatz”) will appear in the two-hander “Blood Knot,” to be helmed by scribe Athol Fugard. The 1961 play centers on mixed-race brothers in South Africa during the era of Apartheid.

Show starts previews Jan. 31 prior to a Feb. 16 opening.

Meanwhile, Tonya Pinkins (“Caroline, or Change,” “Milk Like Sugar”) leads the ensemble of performers on tap for “Hurt Village,” Signature’s world preem of a new play by Katori Hall (“The Mountaintop”). Ron Cephas Jones (“Titus Andronicus”), Saycon Seng-bloh (“Fela!”) and Marsha Stephanie Blake (“Joe Turner’s Come and Gone”) also are among the cast.

Helmed by Patricia McGregor, “Hurt Village” kicks off previews Feb. 7 at the Romulus Linney Courtyard Theater, and opens March 18.