Bebe Neuwirth has signed on to topline Manhattan Theater Club’s upcoming staging of Terrence McNally play “Golden Age.”

Lorenzo Pisoni, whose MTC stint for his solo show “Humor Abuse” helped launch a tour of that title, also will star in the show about the backstage drama during the 1835 premiere of Bellini’s opera “I Puritani” in Paris.

Both thesps portray real-life opera singers in the play, which had its world preem in Philadelphia in 2010 prior to a run at the Kennedy Center. Neuwirth will play Maria Malibran, previously played by Amanda Mason Warren, while Pisoni is onboard as Antonio Tamburini, a role created by Marc Kudisch. Jeffrey Carlson (as composer Bellini) and Rebecca Brooksher also appeared in prior incarnations of “Golden Age,” but further casting for the MTC staging remains to be set.

Production reunites Neuwirth with director Walter Bobbie (“Venus in Fur”), who also helmed the actress in “Chicago,” a show that netted a Tony for each of them. Neuwirth’s last Gotham stage gig was earlier this year in the Classic Stage Company production of “A Midsummer Night Dream.”

“Golden Age” plays MTC’s larger Off Broadway space at City Center for a fall run that begins Nov. 13 ahead of a Dec. 4 opening. MTC’s season kicks off first, though, with a Broadway revival of “An Enemy of the People,” opening at the Samuel J. Friedman Theater in September.