Witherspoon, Reynolds land ‘Big Eyes’

Thesps to star in biopic of artists Margaret and Walter Keane

Reese Witherspoon and Ryan Reynolds are attached to star in the indie “Big Eyes,” a biopic of Margaret and Walter Keane that will be written and directed by Scott Alexander and Larry Karaszewski.

Tim Burton is producing through his Tim Burton Prods. banner, while Lynette Howell and Jamie Patricof will produce through their new shingle Electric City Entertainment. Production is skedded to start this spring.

Based on a true story, pic concerns the Keanes’ pop-eyed paintings, which became a worldwide sensation in the 1960s. However, their lives were fraught with controversy; While Margaret was the true talent who toiled in obscurity, Walter stole all the credit and enjoyed fame.

“We are ecstatic to have this dream cast for our dream project,” the helmers said in a joint statement. “Walter is a larger-than-life antihero — charming, funny, dangerous, and a little crazy. Ryan will knock it out of the park. As for Reese, she will be perfect as Margaret — soulful, decent, transforming from vulnerability to learning to fight for herself.”

Karaszewski and Alexander previously collaborated with Burton on the Oscar-winning Johnny Depp-starrer “Ed Wood.” Their other credits include “The People Vs. Larry Flynt” and the Andy Kaufman pic “Man on the Moon.”

Reynolds next stars opposite Denzel Washington in the action-thriller “Safe House,” which Universal opens Feb. 10.

Witherspoon next stars alongside Chris Pine and Tom Hardy in McG’s action-comedy “This Means War,” which Fox opens Feb. 14.

Alexander and Karaszewski are repped by UTA, while WME reps Burton. CAA reps Reynolds and Witherspoon, who is also repped by Management 360.