The New York Film Festival has tapped David Chase’s feature debut, “Not Fade Away,” as the centerpiece gala selection for the 2012 edition of the fest.

Pic’s world premiere will screen Oct. 6 as part of NYFF, ahead of the film’s Dec. 21 release from Paramount Vantage.

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Written and directed by Chase (“The Sopranos”), “Not Fade Away” centers on a young musician (played by John Magaro) who forms a band with his friends in 1960s New Jersey. James Gandolfini and Brad Garrett also are among the cast, appearing alongside a young ensemble that includes Jack Huston, Will Brill and Bella Heathcote.

“Not Fade Away” is the third film so far announced for NYFF’s main slate, traditionally a short roster of between 25 and 30 films. The 2012 outing is the 50th edition of NYFF, and also marks the final round of programming to be helmed by Richard Pena, the longtime program director who will step down at the end of this year’s festival.

Ang Lee’s 3D offering “Life of Pi” launches the 17-day fest Sept. 28, with Robert Zemeckis’ “Flight,” toplined by Denzel Washington, on the docket for the closing night screening Oct. 14.

Further films on NYFF’s main slate will be announced in the coming days, as will additional programming for sidebar screenings, retrospectives and other events.