Mark Webber and Chloe Sevigny will star in Adam Bhala Lough’s indie relationship drama “Panarea,” with production starting this summer.

Mangusta Prods.’ Sol Tryon and Giancarlo Canavesio have partnered with Mike S. Ryan (“Choke”) to produce. Jim Jarmusch is exec producing.

Story follows a young married couple with intimacy issues who find themselves vacationing on an exotic Italian island where their commitment is tested. Script’s penned by Adam Mansbach, author of “Go the F*ck to Sleep.”

Webber will play an American struggling with what it means to be a man while Sevigny plays a headstrong Swede. It’s the third collaboration between Lough and Webber following “Bomb the System” and “Weapons.”

Webber’s in three premieres at Sundance: “The End of Love,” “Save the Date” and For a Good Time Call…” Sevigny will be seen next in “Sky Atlantic.”

Webber is repped by Innovative Artists. His attorney is Ira Schreck at Schreck, Rose Dapello Adams & Hurwitz. Sevigny is repped by WME and Danny Sussman at Brillstein Entertainment Partners.