Richard Dreyfuss is set to star in Jason Priestley’s road trip comedy, “Cas and Dylan.”

Dreyfuss will play Dr. Cas Pepper, an ailing 61-year-old man who, seeking to end life on his own terms, inadvertently ends up on the lam with a young woman, played by Tatiana Maslany (“The Vow”).

“Cas and Dylan” is Priestley’s feature directorial debut. Thesp currently stars in “Call Me Fitz” and has also been busy directing TV.

Being Erica” scribe Jesse Gabe wrote the script.

Toronto-based Mark Montefiore of Montefiore Films will produce with pic slated to start filming between late August and early September in northern Ontario and Alberta.

Dreyfuss will soon be seen in A&E’s “Coma” alongside Sigourney Weaver and Ellen Burstyn. He has also recently worked on the yet-to-be-released indie pics “Very Good Girls,” with Dakota Fanning, Elizabeth Olsen and Demi Moore, and Robert Luketic’s “Paranoia,” with Harrison Ford, Liam Hemsworth and Gary Oldman.

Dreyfuss is represented by Risa Shapiro at the Shiff Co. and Barry McPherson at APA.

Priestley is repped by Carlos Carreras at APA, Brent Jordan Sherman at the Characters (Canada) and JB Roberts at Thruline.

Maslany is repped by Jennifer Goldhar at the Characters and by Magnolia Entertainment stateside, while Gabe is repped by by Brent Jordan Sherman at the Characters.

Montefiore is repped by Karen Evans at Karen Evans Management.