LONDON — British actor Bob Hoskins is ending his 40-year career after being diagnosed with Parkinson’s Disease.

A statement from his agent on Wednesday said, “Bob is now looking forward to his retirement with his family. He wishes to thank all the people he has worked with over the years, and all his fans who have supported him during a wonderful career.”

The 69-year-old actor rose to prominence with his acclaimed performance as gangster Harold Shand in John Mackenzie’s “The Long Good Friday” in 1980.

His lead role in Neil Jordan’s “Mona Lisa” earned him a best actor award at the Cannes Film Festival in 1986, as well as Golden Globe and BAFTA awards. The performance also brought his one Oscar nomination, where he lost out to Paul Newman in “The Color of Money.”

He was nominated for BAFTA awards on three other occasions and Golden Globes twice more, most recently for his supporting role in Stephen Frears’ “Mrs Henderson Presents,” in 2005. In 2010 he received an Intl. Emmy for actor for his role in the Granada Television production “The Street” for the BBC.

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Hoskins will probably be best remembered for playing Eddie Valiant opposite animated co-stars in Robert Zemeckis’ “Who Framed Roger Rabbit?” in 1988, for which he earned his second Golden Globe nom. He reteamed with Zemeckis on motion-capture animation “A Christmas Carol” in 2009.

Hoskins most recently appeared as one of the dwarves in Universal’s “Snow White and the Huntsman” opposite Kristen Stewart.